NOVEL ANTI-INFLAMMATORY AND ANALGESIC AGENTS OF 5-CHROMENO-PYRIDO[2,3-d]PYRIMIDINE-4-YL DERIVATIVES AND S-NUCLEOSIDES ANALOGOUS
نویسندگان
چکیده
A series of new 3-formyl coumarine (2) was synthesized in good yields by replacement of chlorine atom by 2 amines. In addition, 5-chromeno-pyrido[2,3-d]pyrimidine-4-yl derivatives (5,6) was synthesized by cyclocondensation of 6aminouracil, the respective ketones and 3-formyl coumarine (2) in one pot-synthesis. Also 2-S-nucleosides analogous of pyrido[2,3-d]-pyrimidines (12-15) was synthesized by a simple method in good yields, The new compounds were evaluated for their anti-inflammatory and analgesic activity. It has been found that the derivatives 5a, 5b, 14a, 14b, 15a and 15c exhibited the dual pharmacological activities with superior gastrointestinal safety profile when compared to indomethacin except 5a which resulted in ulcer lesions in many of the experimental rats.
منابع مشابه
Synthesis and evaluation of analgesic, anti-inflammatory and ulcerogenic activities of some triazolo- and 2-pyrazolyl-pyrido[2,3-d]-pyrimidines.
New series of 2-hydrazino-7,8-dihydro-6H-cyclopenta[5,6] pyrido[2,3-d]pyrimidines and its 1,7,8,9-tetrahydrocyclopenta[5,6]pyrido[2,3-d][1,2,4]triazolo[4,3-a]pyrimidine, 1,7,8,9-tetrahydrocyclopenta[5,6]pyrido[2,3-d][1,2,3,4]tetrazolo[4,5-a]pyrimidine, 8,9-dihydro-7H-cyclopenta[5,6]pyrido[2,3-d]imidazolo[1,2-a]pyrimidine, 2-(pyrazol-1-yl)-7,8-dihydro-6H-cyclopenta[5,6]pyrido[2,3-d]pyrimidine de...
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